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Using genetic designs to identify likely causal environmental contributions to psychopathology

Sellers, Ruth, Riglin, Lucy, Harold, Gordon and Thapar, Anita ORCID: 2022. Using genetic designs to identify likely causal environmental contributions to psychopathology. Development and Psychopathology 34 (5) , pp. 1653-1665. 10.1017/S0954579422000906

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The multifactorial nature of psychopathology, whereby both genetic and environmental factors contribute risk, has long been established. In this paper, we provide an update on genetically informative designs that are utilized to disentangle genetic and environmental contributions to psychopathology. We provide a brief reminder of quantitative behavioral genetic research designs that have been used to identify potentially causal environmental processes, accounting for genetic contributions. We also provide an overview of recent molecular genetic approaches that utilize genome-wide association study data which are increasingly being applied to questions relevant to psychopathology research. While genetically informative designs typically have been applied to investigate the origins of psychopathology, we highlight how these approaches can also be used to elucidate potential causal environmental processes that contribute to developmental course and outcomes. We highlight the need to use genetically sensitive designs that align with intervention and prevention science efforts, by considering strengths-based environments to investigate how positive environments can mitigate risk and promote children’s strengths.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: Published in Special Section: Leveraging Genetically Informative Study Designs to Understand the Development and Familial Transmission of Psychopathology
Publisher: Cambridge University Press
ISSN: 0954-5794
Date of First Compliant Deposit: 8 November 2022
Date of Acceptance: 14 July 2022
Last Modified: 15 May 2023 20:14

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