Association of OSR-1 with vascular dysfunction and hypertension in polycystic kidney disease

Kocyigit, Ismail, Taheri, Serpil, Eroglu, Eray, Zararsiz, Gokmen, Sener, Elif Funda, Uzun, Ilknur, Imamoglu, Hakan, Mehmetbeyoglu, Ecmel, Unal, Aydin, Korkmaz, Keziban, Sipahioglu, Murat Hayri, Oymak, Oktay and Tokgoz, Bulent 2020. Association of OSR-1 with vascular dysfunction and hypertension in polycystic kidney disease. Therapeutic Apheresis and Dialysis 24 (1) , pp. 64-71. 10.1111/1744-9987.12814

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Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is associated with oxidative stress and hypertension development before renal function decline and cardiovascular disease development. Oxidative stress-responsive kinase-1 (OSR-1) participates in the signaling regulating Na+ transport during oxidative stress and also plays a role in the regulation of cell volume and blood pressure. Therefore, we aimed to investigate the potential role of OSR-1 in ADPKD patients. Eighty ADPKD patients, 80 healthy controls, and 80 non-ADPKD patients with hypertension were enrolled in this cross-sectional study. Twenty-four-hour ambulatory blood pressure monitoring was conducted in all participants. Blood samples were taken after 12-h fasting for the measurement of biochemical parameters and OSR-1 gene expression. Vascular dysfunction was assessed using ischemia-induced forearm flow-mediated vasodilation (FMD). Briefly, of the 80 ADPKD patients, 41(51%) were male, and 53(66%) of them were hypertensive. The mean age of the 80 controls was 35.3 ± 12.6 years, and 37(46%) of them were male. The mean age of the 80 non-ADPKD patients with hypertension was 44.6 ± 11.9 years, and 38(47.5) of them were male. There were significant differences in serum OSR-1 gene expression between the ADPKD patients and the control subjects. Serum OSR-1 gene expression was also significantly increased in hypertensive ADPKD patients in comparison with both normotensive ADPKD counterparts and non-ADPKD hypertensive subjects. Serum OSR-1 gene expression was increased in patients with ADPKD than healthy subjects. Low estimated glomerular filtration rate (eGFR), OSR-1 gene expression, total kidney volume (TKV), and high-density lipoprotein (HDL) were also independently associated with hypertension in ADPKD patients.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Date of Acceptance:	23 April 2019
Last Modified:	17 Jan 2023 09:51
URI:	https://orca.cardiff.ac.uk/id/eprint/154368

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