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Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination

Buoninfante, Alessandra, Andeweg, Arno, Baker, Alexander T. ORCID: https://orcid.org/0000-0001-8232-0531, Borad, Mitesh, Crawford, Nigel, Dogné, Jean-Michel, Garcia-Azorin, David, Greinacher, Andreas, Helfand, Rita, Hviid, Anders, Kochanek, Stefan, López-Fauqued, Marta, Nazy, Ishac, Padmanabhan, Anand, Pavord, Sue, Prieto-Alhambra, Daniel, Tran, Huyen, Wandel Liminga, Ulla and Cavaleri, Marco 2022. Understanding thrombosis with thrombocytopenia syndrome after COVID-19 vaccination. npj Vaccines 7 (1) , 141. 10.1038/s41541-022-00569-8

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Abstract

Safety and efficacy of vaccines against the SARS-CoV-2 coronavirus has been demonstrated in clinical trials and next by their real world use through the course of the ongoing COVID-19 pandemic. However, very rare adverse events have been detected post-authorization in certain parts of the world. This meeting report summarizes an EMA workshop’s discussion on the epidemiology, clinical presentation and biology of thrombosis with thrombocytopenia syndrome after adenovirus vector COVID-19 vaccination. General agreement was reached by international regulators, scientists and developers on the steps needed to fill the gaps in the characterization of this new syndrome. In particular, actions should be taken to improve the post-vaccination surveillance activities in low and middle income countries and investigate potential genetic predisposition factors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Nature Research
ISSN: 2059-0105
Date of First Compliant Deposit: 21 December 2022
Date of Acceptance: 21 October 2022
Last Modified: 07 May 2023 12:56
URI: https://orca.cardiff.ac.uk/id/eprint/155084

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