Chemical synthesis of peptides and their biological applications as mitochondria-targeting chemotherapeutics

Cardella, Davide 2022. Chemical synthesis of peptides and their biological applications as mitochondria-targeting chemotherapeutics. PhD Thesis, Cardiff University. Item availability restricted.

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Abstract

Synthetic peptides are of great use in many areas of chemical biology and drug discovery. This PhD thesis details new synthetic approaches for the preparation of peptide molecules, along with applications of synthetic peptide derivatives as chemotherapeutics agents. In this work, I give an overview on peptides and their applications in the chemical biology research area (Chapter 1). Then, I start illustrating my experimental work by exploring a new method for the total synthesis of peptides and proteins on solid phase (Chapter 2). Next, I investigate the effect of conjugating a mitochondria- and a cancer cell-targeting motif to reported proapoptotic peptides, to enhance their potency and selectivity profiles (Chapter 3 and 4). Finally, I give a brief review and outline the future directions towards addressing the limitations of the presented projects (Chapter 5).

Item Type:	Thesis (PhD)
Date Type:	Completion
Status:	Unpublished
Schools:	Chemistry
Date of First Compliant Deposit:	23 December 2022
Last Modified:	23 Dec 2023 02:30
URI:	https://orca.cardiff.ac.uk/id/eprint/155238

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