Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface

Azizova, Liana R., Kulik, Tetiana, Palianytsia, Borys B., Telbiz, German M. and Kartel, Mykola T. 2021. Secondary structure of muramyl dipeptide glycoside in pristine state and immobilized on nanosilica surface. Colloids and Surfaces A: Physicochemical and Engineering Aspects 631 , pp. 1-8. 10.1016/j.colsurfa.2021.127724

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Abstract

Fourier transform infrared spectroscopy (FT-IR) and temperature programmed desorption mass spectrometry (TPD-MS) data of O-glycoside MDP in pristine and immobilized on silica surface states indicate that O-glycoside MDP binds to the silica surface by means of carboxylic and NH moieties of isoglutamine. Moreover, pyrolysis of O-glycoside MDP on the silica surface proceeds through formation of additional product 3-iminopyridine-2(3H)-one, which identified in mass spectra as molecular ion with m/z 108 and its fragment ions with m/z 79, 77, 51. FTIR and TPD-MS data confirm existence of a MDP first β-turn on the silica surface resulting from the formation of a hydrogen bond between the NAc carbonyl and the L-Ala NH for MDP and its analogs, as reported previously.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
ISSN:	1873-4359
Date of First Compliant Deposit:	18 April 2023
Date of Acceptance:	8 October 2021
Last Modified:	15 Nov 2023 17:24
URI:	https://orca.cardiff.ac.uk/id/eprint/155290

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