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Advances in the genetics of stroke risk and recovery

Majumder, Sabbiha Nadia, Hrastelj, James and Robertson, Neil P. ORCID: 2023. Advances in the genetics of stroke risk and recovery. Journal of Neurology 270 (1) , pp. 590-591. 10.1007/s00415-022-11525-w

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Cerebrovascular disease (CVD) is widely considered a heterogeneous clinical syndrome rather than a single disorder. A large number of modifiable and non-modifiable risk factors have been associated with CVD, but even after accounting for these, there remains a large proportion of unexplained individual risk. Although genetic risk has commonly been considered non-modifiable, it is now better understood how environmental influences can modify gene expression as a result of epigenetic phenomena. Genome-Wide Association Studies (GWAS) have identified some genetic risk loci for stroke, many of which are common to CVD in general. It is hoped that a more comprehensive understanding of genetic risk in differing populations will have the potential to improve our understanding of disease pathogenesis and to identify novel therapeutic mechanisms. This in turn could be used to quantify risk of stroke at a young age, integrate with advice on lifestyle choices, and develop opportunities to target preventive treatments.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: Springer
ISSN: 0340-5354
Date of First Compliant Deposit: 6 January 2023
Date of Acceptance: 12 December 2022
Last Modified: 05 May 2023 21:25

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