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The liv-1 subfamily of zinc transporters: from origins to present day discoveries

Taylor, Kathryn M. ORCID: 2023. The liv-1 subfamily of zinc transporters: from origins to present day discoveries. International Journal of Molecular Sciences 24 (2) , 1255. 10.3390/ijms24021255

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first_pagesettingsOrder Article Reprints Open AccessReview The LIV-1 Subfamily of Zinc Transporters: From Origins to Present Day Discoveries by Kathryn M. TaylorORCID School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Redwood Building, King Edward VIIth Avenue, Cardiff CF10 3NB, UK Int. J. Mol. Sci. 2023, 24(2), 1255; Received: 13 December 2022 / Revised: 3 January 2023 / Accepted: 6 January 2023 / Published: 9 January 2023 (This article belongs to the Special Issue Current Topics in Trace Element and Mineral Research) Download Browse Figures Review Reports Versions Notes Abstract This review explains the origin of the LIV-1 family of zinc transporters, paying attention to how this family of nine human proteins was originally discovered. Structural and functional differences between these nine human LIV-1 family members and the five other ZIP transporters are examined. These differences are both related to aspects of the protein sequence, the conservation of important motifs and to the effect this may have on their overall function. The LIV-1 family are dependent on various post-translational modifications, such as phosphorylation and cleavage, which play an important role in their ability to transport zinc. These modifications and their implications are discussed in detail. Some of these proteins have been implicated in cancer which is examined. Furthermore, some additional areas of potential fruitful discovery are discussed and suggested as worthy of examination in the future.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Pharmacy
Publisher: MDPI
ISSN: 1422-0067
Date of First Compliant Deposit: 13 January 2023
Date of Acceptance: 6 January 2023
Last Modified: 06 May 2023 21:29

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