Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures

McCafferty, Cian, Gruenbaum, Benjamin F., Tung, Renee, Li, Jing-Jing, Zheng, Xinyuan, Salvino, Peter, Vincent, Peter, Kratochvil, Zachary, Ryu, Jun Hwan, Khalaf, Aya, Swift, Kohl, Akbari, Rashid, Islam, Wasif, Antwi, Prince, Johnson, Emily A., Vitkovskiy, Petr, Sampognaro, James, Freedman, Isaac G., Kundishora, Adam, Depaulis, Antoine, David, François, Crunelli, Vincenzo ORCID:, Sanganahalli, Basavaraju G., Herman, Peter, Hyder, Fahmeed and Blumenfeld, Hal 2023. Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures. Nature Communications 14 (1) 10.1038/s41467-022-35535-4

[thumbnail of s41467-022-35535-4.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (3MB) | Preview


Absence seizures are brief episodes of impaired consciousness, behavioral arrest, and unresponsiveness, with yet-unknown neuronal mechanisms. Here we report that an awake female rat model recapitulates the behavioral, electroencephalographic, and cortical functional magnetic resonance imaging characteristics of human absence seizures. Neuronally, seizures feature overall decreased but rhythmic firing of neurons in cortex and thalamus. Individual cortical and thalamic neurons express one of four distinct patterns of seizure-associated activity, one of which causes a transient initial peak in overall firing at seizure onset, and another which drives sustained decreases in overall firing. 40–60 s before seizure onset there begins a decline in low frequency electroencephalographic activity, neuronal firing, and behavior, but an increase in higher frequency electroencephalography and rhythmicity of neuronal firing. Our findings demonstrate that prolonged brain state changes precede consciousness-impairing seizures, and that during seizures distinct functional groups of cortical and thalamic neurons produce an overall transient firing increase followed by a sustained firing decrease, and increased rhythmicity.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Nature Research
Date of First Compliant Deposit: 24 January 2023
Date of Acceptance: 8 December 2022
Last Modified: 03 May 2023 07:37

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics