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Heterogeneity and diversity of striatal GABAergic interneurons: update 2018

Tepper, James M., Koós, Tibor, Ibanez-Sandoval, Osvaldo, Tecuapetla, Fatuel, Faust, Thomas W. and Assous, Maxime 2018. Heterogeneity and diversity of striatal GABAergic interneurons: update 2018. Frontiers in Neuroanatomy 12 10.3389/fnana.2018.00091

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Our original review, “Heterogeneity and Diversity of Striatal GABAergic Interneurons,” to which this is an invited update, was published in December, 2010 in Frontiers is Neuroanatomy. In that article, we reviewed several decades’ worth of anatomical and electrophysiological data on striatal parvalbumin (PV)-, neuropeptide Y (NPY)- and calretinin(CR)-expressing GABAergic interneurons from many laboratories including our own. In addition, we reported on a recently discovered novel tyrosine hydroxylase (TH) expressing GABAergic interneuron class first revealed in transgenic TH EGFP reporter mouse line. In this review, we report on further advances in the understanding of the functional properties of previously reported striatal GABAergic interneurons and their synaptic connections. With the application of new transgenic fluorescent reporter and Cre-driver/reporter lines, plus optogenetic, chemogenetic and viral transduction methods, several additional subtypes of novel striatal GABAergic interneurons have been discovered, as well as the synaptic networks in which they are embedded. These findings make it clear that previous hypotheses in which striatal GABAergic interneurons modulate and/or control the firing of spiny neurons principally by simple feedforward and/or feedback inhibition are at best incomplete. A more accurate picture is one in which there are highly selective and specific afferent inputs, synaptic connections between different interneuron subtypes and spiny neurons and among different GABAergic interneurons that result in the formation of functional networks and ensembles of spiny neurons.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Frontiers Media
ISSN: 1662-5129
Date of First Compliant Deposit: 25 January 2023
Date of Acceptance: 12 October 2018
Last Modified: 03 May 2023 07:20

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