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Differential processing of thalamic information via distinct striatal interneuron circuits

Assous, Maxime, Kaminer, Jaime, Shah, Fulva, Garg, Arpan, Koós, Tibor and Tepper, James M. 2017. Differential processing of thalamic information via distinct striatal interneuron circuits. Nature Communications 8 (1) , pp. 3642-3659. 10.1038/ncomms15860

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Recent discoveries of striatal GABAergic interneurons require a new conceptualization of the organization of intrastriatal circuitry and their cortical and thalamic inputs. We investigated thalamic inputs to the two populations of striatal neuropeptide Y (NPY) interneurons, plateau low threshold spike (PLTS) and NPY-neurogliaform (NGF) cells. Optogenetic activation of parafascicular inputs evokes suprathreshold monosynaptic glutamatergic excitation in NGF interneurons and a disynaptic, nicotinic excitation through cholinergic interneurons. In contrast, the predominant response of PLTS interneurons is a disynaptic inhibition dependent on thalamic activation of striatal tyrosine hydroxylase interneurons (THINs). In contrast, THINs do not innervate NGF or fast spiking interneurons, showing significant specificity in THINs outputs. Chemospecific ablation of THINs impairs prepulse inhibition of the acoustic startle response suggesting an important behavioural role of this disynaptic pathway. Our findings demonstrate that the impact of the parafascicular nucleus on striatal activity and some related behaviour critically depend on synaptic interactions within interneuronal circuits.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Nature Research
Date of First Compliant Deposit: 25 January 2023
Date of Acceptance: 3 May 2017
Last Modified: 03 May 2023 07:21

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