Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Osteopontin and cancer: insights into its role in drug resistance

Hao, Chengcheng, Lane, Jane ORCID: and Jiang, Wen G. ORCID: 2023. Osteopontin and cancer: insights into its role in drug resistance. Biomedicines 11 (1) , 197. 10.3390/biomedicines11010197

[thumbnail of biomedicines-11-00197-v2.pdf] PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB)


Cancer is one of the leading causes of mortality worldwide. Currently, drug resistance is the main obstacle in cancer treatments with the underlying mechanisms of drug resistance yet to be fully understood. Osteopontin (OPN) is a member of the integrin binding glycophosphoprotein family that is overexpressed in several tumour types. It is involved in drug transport, apoptosis, stemness, energy metabolism, and autophagy, which may contribute to drug resistance. Thus, understanding the role of OPN in cancer drug resistance could be important. This review describes the OPN-based mechanisms that might contribute to cancer drug resistance, demonstrating that OPN may be a viable target for cancer therapy to reduce drug resistance in sensitive tumours.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: ?? VCO ??
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: MDPI
Date of First Compliant Deposit: 6 February 2023
Date of Acceptance: 9 January 2023
Last Modified: 29 Apr 2024 19:07

Citation Data

Cited 9 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics