Osteopontin and cancer: insights into its role in drug resistance

Hao, Chengcheng, Lane, Jane ORCID: https://orcid.org/0000-0002-1926-4909 and Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 2023. Osteopontin and cancer: insights into its role in drug resistance. Biomedicines 11 (1) , 197. 10.3390/biomedicines11010197

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Abstract

Cancer is one of the leading causes of mortality worldwide. Currently, drug resistance is the main obstacle in cancer treatments with the underlying mechanisms of drug resistance yet to be fully understood. Osteopontin (OPN) is a member of the integrin binding glycophosphoprotein family that is overexpressed in several tumour types. It is involved in drug transport, apoptosis, stemness, energy metabolism, and autophagy, which may contribute to drug resistance. Thus, understanding the role of OPN in cancer drug resistance could be important. This review describes the OPN-based mechanisms that might contribute to cancer drug resistance, demonstrating that OPN may be a viable target for cancer therapy to reduce drug resistance in sensitive tumours.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	?? VCO ?? Medicine
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
Date of First Compliant Deposit:	6 February 2023
Date of Acceptance:	9 January 2023
Last Modified:	03 May 2023 21:18
URI:	https://orca.cardiff.ac.uk/id/eprint/156523

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