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Differential serotonergic modulation of synaptic inputs to the olfactory cortex

Piszár, Ildikó and Lőrincz, Magor L. 2023. Differential serotonergic modulation of synaptic inputs to the olfactory cortex. International Journal of Molecular Sciences 24 (3) , 1950. 10.3390/ijms24031950

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Serotonin (5-hydroxytriptamine, 5-HT) is an important monoaminergic neuromodulator involved in a variety of physiological and pathological functions. It has been implicated in the regulation of sensory functions at various stages of multiple modalities, but its mechanisms and functions in the olfactory system have remained elusive. Combining electrophysiology, optogenetics and pharmacology, here we show that afferent (feed-forward) pathway-evoked synaptic responses are boosted, whereas feedback responses are suppressed by presynaptic 5-HT1B receptors in the anterior piriform cortex (aPC) in vitro. Blocking 5-HT1B receptors also reduces the suppressive effects of serotonergic photostimulation of baseline firing in vivo. We suggest that by regulating the relative weights of synaptic inputs to aPC, 5-HT finely tunes sensory inputs in the olfactory cortex.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: MDPI
ISSN: 1661-6596
Date of First Compliant Deposit: 6 February 2023
Date of Acceptance: 6 January 2023
Last Modified: 02 Jul 2023 13:18

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