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Watching living cells in action in the exocrine pancreas: the palade prize lecture

Petersen, Ole H ORCID: 2022. Watching living cells in action in the exocrine pancreas: the palade prize lecture. Function 4 (1) , zqac061. 10.1093/function/zqac061

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George Palade’s pioneering electron microscopical studies of the pancreatic acinar cell revealed the intracellular secretory pathway from the rough endoplasmic reticulum at the base of the cell to the zymogen granules in the apical region. Palade also described for the first time the final stage of exocytotic enzyme secretion into the acinar lumen. The contemporary studies of the mechanism by which secretion is acutely controlled, and how the pancreas is destroyed in the disease acute pancreatitis, rely on monitoring molecular events in the various identified pancreatic cell types in the living pancreas. These studies have been carried out with the help of high-resolution fluorescence recordings, often in conjunction with patch clamp current measurements. In such studies we have gained much detailed information about the regulatory events in the exocrine pancreas in health as well as disease, and new therapeutic opportunities have been revealed.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Publisher: Oxford University Press
ISSN: 2633-8823
Date of First Compliant Deposit: 13 February 2023
Date of Acceptance: 5 December 2022
Last Modified: 08 May 2023 04:58

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