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WAO consensus on DEfinition of Food Allergy SEverity (DEFASE)

Arasi, Stefania, Nurmatov, Ulugbek, Dunn-Galvin, Audrey, Roberts, Graham, Turner, Paul J., Shinder, Sayantani B., Gupta, Ruchi, Eigenmann, Philippe, Nowak-Wegrzyn, Anna, Ansotegui, Ignacio J., Rivas, Montserrat Fernandez, Petrou, Stavros, Tanno, Luciana K., Vazquez-Ortiz, Marta, Vickery, Brian, Wong, Gary, Alvaro-Lozano, Montserrat, Asaria, Miqdad, Begin, Philippe, Bozzola, Martin, Boyle, Robert, Brough, Helen, Cardona, Victoria, Chinthrajah, R. Sharon, Cianferoni, Antonella, Deschildre, Antoine, Fleischer, David, Gazzani, Flavio, Gerdts, Jennifer, Giannetti, Marilena, Greenhawt, Matthew, Guzmán, Maria Antonieta, Hossny, Elham, Kauppi, Paula, Jones, Carla, Lucidi, Francesco, Monge Ortega, Olga Patricia, Munblit, Daniel, Muraro, Antonella, Pajno, Giovanni, Podestà, Marcia, Rodriguez del Rio, Pablo, Said, Maria, Santos, Alexandra, Shaker, Marcus, Szajewska, Hania, Venter, Carina, Warren, Cristopher, Winders, Tonya, Ebisawa, Motohiro and Fiocchi, Alessandro 2023. WAO consensus on DEfinition of Food Allergy SEverity (DEFASE). World Allergy Organization Journal 16 (3) , 100753. 10.1016/j.waojou.2023.100753

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Background While several scoring systems for the severity of anaphylactic reactions have been developed, there is a lack of consensus on definition and categorisation of severity of food allergy disease as a whole. Aim To develop an international consensus on the severity of food allergy (DEfinition of Food Allergy Severity, DEFASE) scoring system, to be used globally. Methods: Phase 1 We conducted a mixed-method systematic review (SR) of 11 databases for published and unpublished literature on severity of food allergy management and set up a panel of international experts. Phase 2 Based on our findings in Phase 1, we drafted statements for a two-round modified electronic Delphi (e-Delphi) survey. A purposefully selected multidisciplinary international expert panel on food allergy (n = 60) was identified and sent a structured questionnaire, including a set of statements on different domains of food allergy severity related to symptoms, health-related quality of life, and economic impact. Participants were asked to score their agreement on each statement on a 5-point Likert scale ranging from “strongly agree” to “strongly disagree”. Median scores and percentage agreements were calculated. Consensus was defined a priori as being achieved if 70% or more of panel members rated a statement as “strongly agree” to “agree” after the second round. Based on feedback, 2 additional online voting rounds were conducted. Results We received responses from 92% of Delphi panel members in round 1 and 85% in round 2. Consensus was achieved on the overall score and in all of the 5 specific key domains as essential components of the DEFASE score. Conclusions The DEFASE score is the first comprehensive grading of food allergy severity that considers not only the severity of a single reaction, but the whole disease spectrum. An international consensus has been achieved regarding a scoring system for food allergy disease. It offers an evaluation grid, which may help to rate the severity of food allergy. Phase 3 will involve validating the scoring system in research settings, and implementing it in clinical practice.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: License information from Publisher: LICENSE 1: URL:, Start Date: 2023-02-08
Publisher: Elsevier
ISSN: 1939-4551
Date of First Compliant Deposit: 6 March 2023
Date of Acceptance: 3 February 2023
Last Modified: 03 May 2023 09:05

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