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Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course

Muri, Jonathan, Cecchinato, Valentina, Cavalli, Andrea, Shanbhag, Akanksha A., Matkovic, Milos, Biggiogero, Maira, Maida, Pier Andrea, Moritz, Jacques, Toscano, Chiara, Ghovehoud, Elaheh, Furlan, Raffaello, Barbic, Franca, Voza, Antonio, De Nadai, Guendalina, Cervia, Carlo, Zurbuchen, Yves, Taeschler, Patrick, Murray, Lilly A., Danelon-Sargenti, Gabriela, Moro, Simone, Gong, Tao, Piffaretti, Pietro, Bianchini, Filippo, Crivelli, Virginia, Podešvová, Lucie, Pedotti, Mattia, Jarrossay, David, Sgrignani, Jacopo, Thelen, Sylvia, Uhr, Mario, Bernasconi, Enos, Rauch, Andri, Manzo, Antonio, Ciurea, Adrian, Rocchi, Marco B. L., Varani, Luca, Moser, Bernhard ORCID:, Bottazzi, Barbara, Thelen, Marcus, Fallon, Brian A., Boyman, Onur, Mantovani, Alberto, Garzoni, Christian, Franzetti-Pellanda, Alessandra, Uguccioni, Mariagrazia and Robbiani, Davide F. 2023. Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course. Nature Immunology 24 (4) , pp. 604-611. 10.1038/s41590-023-01445-w

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Infection with severe acute respiratory syndrome coronavirus 2 associates with diverse symptoms, which can persist for months. While antiviral antibodies are protective, those targeting interferons and other immune factors are associated with adverse coronavirus disease 2019 (COVID-19) outcomes. Here we discovered that antibodies against specific chemokines were omnipresent post-COVID-19, were associated with favorable disease outcome and negatively correlated with the development of long COVID at 1 yr post-infection. Chemokine antibodies were also present in HIV-1 infection and autoimmune disorders, but they targeted different chemokines compared with COVID-19. Monoclonal antibodies derived from COVID-19 convalescents that bound to the chemokine N-loop impaired cell migration. Given the role of chemokines in orchestrating immune cell trafficking, naturally arising chemokine antibodies may modulate the inflammatory response and thus bear therapeutic potential.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: Nature Research
ISSN: 1529-2908
Date of First Compliant Deposit: 31 March 2023
Date of Acceptance: 27 January 2023
Last Modified: 04 May 2023 09:10

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