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Metabolic consequences of the water we drink: a study based on field evidence and animal model experimentation

Wolfart, Janaína Caroline, Theodoro, João Lucas, Silva, Fernanda Coleraus, de Oliveira, Cíntia Mara Ribas, Ferreira, Nuno G. C. and Bittencourt Guimarães, Ana Tereza 2023. Metabolic consequences of the water we drink: a study based on field evidence and animal model experimentation. Toxics 11 (4) , 315. 10.3390/toxics11040315

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The effect of the chronic consumption of water contaminated with residual concentrations of DDT’s metabolites (DDD—dichlorodiphenyldichloroethane and DDE—dichlorodiphenyldichloroethylene) found in the environment were evaluated on the biometric, hematological and antioxidant system parameters of the hepatic, muscular, renal and nervous tissues of Wistar rats. The results showed that the studied concentrations (0.002 mg.L−1 of DDD plus 0.005 mg.L−1 of DDE) could not cause significant changes in the hematological parameters. However, the tissues showed significant alteration in the activity of the antioxidant system represented by the increase in the activity of the enzymes gluthathione S-transferases in the liver, superoxide dismutase in the kidney, gluthathione peroxidase in the brain, and several changes in enzymatic activity in muscle (SOD, GPx and LPO). The enzymes alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) were also evaluated for the amino acids’ metabolism in the liver, with ALT showing a significant increase in the exposed animals. In the integrative analysis of biomarkers (Permanova and PCOA), the studied concentrations showed possible metabolic changes and damage to cellular structures evidenced by increased oxidative stress and body weight gain among the treated animals. This study highlights the need for further studies on the impact of banned pesticides still present in soils that may induce adverse effects in organisms that may prevail in future generations and the environment.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: MDPI
Date of First Compliant Deposit: 6 April 2023
Date of Acceptance: 23 March 2023
Last Modified: 05 May 2023 03:06

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