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Antimicrobial activity of Citrox (R) bioflavonoid preparations against oral microorganisms

Hooper, Samuel James, Lewis, Michael Alexander Oxenham ORCID:, Wilson, Melanie J. ORCID: and Williams, David Wynne ORCID: 2011. Antimicrobial activity of Citrox (R) bioflavonoid preparations against oral microorganisms. British Dental Journal 210 (1) 10.1038/sj.bdj.2010.1224

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Background Citrox (R) is a formulation of soluble bioflavonoids obtained from citrus fruits. The non-toxic and antimicrobial properties of natural bioflavonoids are well documented, and consequently there has been interest in the therapeutic application of these substances. Objective To determine the antimicrobial activity of two Citrox (R) formulations (BC30 and MDC30) with different bioflavonoid combinations against a range of oral microorganisms. Methods The antimicrobial activity of both formulations was tested against 14 bacterial species and six Candida species. The two Citrox (R) formulations (dilution range 0.007-8% v/v) were firstly evaluated by determining the in vitro Minimal Inhibitory Concentration (MIC) against planktonic microorganisms in a broth microdilution assay. Secondly, the ability of the same serial dilutions to inhibit microbial growth was assessed in a modified microtitre biofilm assay. Results Both Citrox (R) formulations exhibited antimicrobial activity. The BC30 formulation demonstrated greater activity than MDC30 and significantly inhibited growth of all bacterial species and most candidal species tested at a concentration of 1% (v/v) in both the broth and the biofilm assay. Conclusion Bioflavonoid preparations of Citrox (R) have a broad-spectrum of antimicrobial activity against oral microorganisms, and as such have the potential to be used within therapeutic preparations for the control of the oral microflora.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Uncontrolled Keywords: resistant staphylococcus-aureus, bioactive plant-extracts, gram-negative bacilli, in-vitro, mouthwash use, efficacy, candida, cancer, alternatives, polyphenols,
Additional Information: Br. Dent. J.
Publisher: Nature Publishing Group
ISSN: 0007-0610
Last Modified: 18 Oct 2022 13:55

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