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Exploring the Link between Microorganisms and Oral Cancer: a Systematic Review of the Literature

Hooper, Samuel James, Wilson, Melanie J. ORCID: and Crean, S. J. 2009. Exploring the Link between Microorganisms and Oral Cancer: a Systematic Review of the Literature. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 31 (9) , pp. 1228-1239. 10.1002/hed.21140

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The majority of cases of oral cancer have been related to tobacco use and heavy alcohol consumption. However, the incidence of oral cavity carcinoma appears to be increasing in many parts of the world in a manner that it is difficult to explain with traditional risk factors alone. Meanwhile, interest in the possible relationships between microorganisms and the different stages of cancer development has been rising and numerous mechanisms by which bacteria and yeast may initiate or promote carcinogenesis are currently under investigation. In particular, a persuasive body of evidence suggests a possible etiological role involving the metabolism and production of carcinogenic products, such as acetaldehyde. Other suggested mechanisms include the induction of chronic inflammation and direct interference with eukaryotic cell cycle and signaling pathways. This review aims to summarize the known associations between microbial infection and cancer and draw attention to how they may relate to oral carcinoma. (C) 2009 Wiley Periodicals, Inc. Head Neck 31: 1228-1239, 2009

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Uncontrolled Keywords: oral cancer; carcinogenesis; oral microflora; candida; bacterial infection
Publisher: Wiley
ISSN: 1043-3074
Last Modified: 18 Oct 2022 13:55

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