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Pressurized intraperitoneal aerosol chemotherapy (PIPAC): updated systematic review using the IDEAL framework

Baggaley, Alice E, Lafaurie, Guillaume B R C, Tate, Sophia J, Boshier, Piers R, Case, Amy, Prosser, Susan, Torkington, Jared, Jones, Sadie E F, Gwynne, Sarah H and Peters, Christopher J 2022. Pressurized intraperitoneal aerosol chemotherapy (PIPAC): updated systematic review using the IDEAL framework. British Journal of Surgery 110 (1) 10.1093/bjs/znac284

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Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a surgical innovation deployed to treat peritoneal metastases. Traditionally, peritoneal metastases have been treated with systemic chemotherapy, but this approach is limited by poor peritoneal perfusion. Intra-abdominal chemotherapy in the form of heated lavage (hyperthermic intraperitoneal chemotherapy (HIPEC)) is currently used alongside cytoreductive surgery. The use of aerosolized agents in a laparoscopic setting was first described in 2000 in a swine model1; since then, a number of PIPAC studies have been reported. The IDEAL framework2 provides recommendations for the design, development, and reporting of studies for novel surgical interventions (Table 1). It recommends that innovations move through stages (idea, development, exploration, assessment, and long-term studies).

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Oxford University Press
ISSN: 0007-1323
Date of First Compliant Deposit: 15 May 2023
Date of Acceptance: 19 July 2022
Last Modified: 20 May 2023 10:52

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