Experience dependent plasticity of higher visual cortical areas in the mouse

Craddock, Rosie, Vasalauskaite, Asta, Ranson, Adam ORCID: https://orcid.org/0000-0002-4804-0832 and Sengpiel, Frank ORCID: https://orcid.org/0000-0002-7060-1851 2023. Experience dependent plasticity of higher visual cortical areas in the mouse. Cerebral Cortex 33 (15) , pp. 9303-9312. 10.1093/cercor/bhad203

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Abstract

Experience dependent plasticity in the visual cortex is a key paradigm for the study of mechanisms underpinning learning and memory. Despite this, studies involving manipulating visual experience have largely been limited to the primary visual cortex, V1, across various species. Here we investigated the effects of monocular deprivation (MD) on the ocular dominance (OD) and orientation selectivity of neurons in four visual cortical areas in the mouse: the binocular zone of V1 (V1b), the putative “ventral stream” area LM and the putative “dorsal stream” areas AL and PM. We employed two-photon calcium imaging to record neuronal responses in young adult mice before MD, immediately after MD, and following binocular recovery. OD shifts following MD were greatest in LM and smallest in AL and PM; in LM and AL, these shifts were mediated primarily through a reduction of deprived-eye responses, in V1b and LM through an increase in response through the non-deprived eye. The OD index recovered to pre-MD levels within 2 weeks in V1 only. MD caused a reduction in orientation selectivity of deprived-eye responses in V1b and LM only. Our results suggest that changes in OD in higher visual areas are not uniformly inherited from V1.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Neuroscience and Mental Health Research Institute (NMHRI) Biosciences
Publisher:	Oxford University Press
ISSN:	1047-3211
Date of First Compliant Deposit:	30 May 2023
Date of Acceptance:	20 May 2023
Last Modified:	10 Feb 2024 02:18
URI:	https://orca.cardiff.ac.uk/id/eprint/160033

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