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Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen †

Dempsey, Seán D., Ryan, Ailbhe A., Smyth, Megan, Moody, Thomas S., Wharry, Scott, Fahey, Karen, Beale, Andrew M., Mediavilla Madrigal, Sofia, Dingwall, Paul, Rooney, David W., Knipe, Peter C., Muldoon, Mark J. and Thompson, Jillian M. 2023. Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen †. Reaction Chemistry and Engineering 10.1039/d3re00195d

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Abstract

The continuous catalytic transfer hydrogenation of benzonitrile to benzylamine is demonstrated using a palladium on carbon catalyst with triethylammonium formate as reducing agent. Solvent choice was critical in overcoming rapid catalyst deactivation. A 15-fold increase in catalyst productivity was observed in flow compared to batch, which was achieved using an ethanol–water solvent in combination with intermittent catalyst regeneration by washing with water.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Chemistry
Additional Information: License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/3.0/, Start Date: 2023-06-16
Publisher: Royal Society of Chemistry
Date of First Compliant Deposit: 19 June 2023
Date of Acceptance: 8 June 2023
Last Modified: 20 Jun 2023 07:04
URI: https://orca.cardiff.ac.uk/id/eprint/160440

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