Placental magnetic resonance imaging in chronic hypertension: A case-control study

Ho, Alison, Hutter, Jana, Slator, Paddy ORCID: https://orcid.org/0000-0001-6967-989X, Jackson, Laurence, Seed, Paul T., Mccabe, Laura, Al-Adnani, Mudher, Marnerides, Andreas, George, Simi, Story, Lisa, Hajnal, Joseph V., Rutherford, Mary and Chappell, Lucy C. 2020. Placental magnetic resonance imaging in chronic hypertension: A case-control study. Placenta 104 , pp. 138-145. 10.1016/j.placenta.2020.12.006

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Abstract

Introduction We aimed to explore the use of magnetic resonance imaging (MRI) in vivo as a tool to elucidate the placental phenotype in women with chronic hypertension. Methods In case-control study, women with chronic hypertension and those with uncomplicated pregnancies were imaged using either a 3T Achieva or 1.5T Ingenia scanner. T2-weighted images, diffusion weighted and T1/T2* relaxometry data was acquired. Placental T2*, T1 and apparent diffusion coefficient (ADC) maps were calculated. Results 129 women (43 with chronic hypertension and 86 uncomplicated pregnancies) were imaged at a median of 27.7 weeks’ gestation (interquartile range (IQR) 23.9–32.1) and 28.9 (IQR 26.1–32.9) respectively. Visual analysis of T2-weighted imaging demonstrated placentae to be either appropriate for gestation or to have advanced lobulation in women with chronic hypertension, resulting in a greater range of placental mean T2* values for a given gestation, compared to gestation-matched controls. Both skew and kurtosis (derived from histograms of T2* values across the whole placenta) increased with advancing gestational age at imaging in healthy pregnancies; women with chronic hypertension had values overlapping those in the control group range. Upon visual assessment, the mean ADC declined in the third trimester, with a corresponding decline in placental mean T2* values and showed an overlap of values between women with chronic hypertension and the control group. Discussion A combined placental MR examination including T2 weighted imaging, T2*, T1 mapping and diffusion imaging demonstrates varying placental phenotypes in a cohort of women with chronic hypertension, showing overlap with the control group.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Computer Science & Informatics
Publisher:	Elsevier
ISSN:	0143-4004
Date of First Compliant Deposit:	3 July 2023
Date of Acceptance:	9 December 2020
Last Modified:	04 Jul 2023 02:07
URI:	https://orca.cardiff.ac.uk/id/eprint/160738

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