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Targeted memory reactivation in human REM sleep elicits detectable reactivation

Abdellahi, Mahmoud, Koopman, Anne, Treder, Matthias ORCID: https://orcid.org/0000-0001-5955-2326 and Lewis, Penelope ORCID: https://orcid.org/0000-0003-1793-3520 2023. Targeted memory reactivation in human REM sleep elicits detectable reactivation. eLife 12 , e84324. 10.7554/elife.84324

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Abstract

It is now well established that memories can reactivate during non-rapid eye movement sleep (non-REM), but the question of whether equivalent reactivation can be detected in rapid eye movement (REM) sleep is hotly debated. To examine this, we used a technique called targeted memory reactivation (TMR) in which sounds are paired with learned material in wake, and then re-presented in subsequent sleep, in this case REM, to trigger reactivation. We then used machine learning classifiers to identify reactivation of task related motor imagery from wake in REM sleep. Interestingly, the strength of measured reactivation positively predicted overnight performance improvement. These findings provide the first evidence for memory reactivation in human REM sleep after TMR that is directly related to brain activity during wakeful task performance.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Computer Science & Informatics
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: eLife Sciences Publications
ISSN: 2050-084X
Date of First Compliant Deposit: 3 July 2023
Date of Acceptance: 22 June 2023
Last Modified: 16 Aug 2023 07:34
URI: https://orca.cardiff.ac.uk/id/eprint/160776

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