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Optic neuritis and MOGAD

Htet, Z. M. and Tallantyre, E. ORCID: 2023. Optic neuritis and MOGAD. Journal of Neurology 270 (6) , 3278–3279. 10.1007/s00415-023-11738-7

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Optic neuritis (ON) is one of the most common causes of monocular visual loss but has several mimics that result in relatively frequent misdiagnosis. In recent years, there has been a growing recognition of the distinct entities of antibody-associated ON (associated with antibodies to myelin oligodendrocyte glycoprotein (MOG) or Aquaporin 4 (AQP4), which have implications for treatment. Some cases of ON represent the first symptom of multiple sclerosis, whilst other cases of ON are (para)infectious or associated with alternate causes of more widespread systemic inflammatory disease. The prevalence of these aetiologies varies according to age, geographical location, and ethnicity. Imaging of the optic nerve using MRI and OCT has continued to improve over recent years as well as becoming more available and has facilitated diagnosis. However, consensus definitions for classification and diagnostic criteria have been lacking. In this month’s journal club, we present a consensus paper that proposes new criteria for the diagnosis of ON, and two papers reporting the clinical features of MOG-antibody-associated disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: Springer
ISSN: 0340-5354
Date of First Compliant Deposit: 10 July 2023
Date of Acceptance: 17 April 2023
Last Modified: 08 May 2024 18:29

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