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Limited impact of discretization/interpolation parameters on the predictive power of CT radiomic features in a surgical cohort of pancreatic cancer patients

Loi, Sara, Mori, Martina, Palumbo, Diego, Crippa, Stefano, Palazzo, Gabriele, Spezi, Emiliano ORCID: https://orcid.org/0000-0002-1452-8813, Del Vecchio, Antonella, Falconi, Massimo, De Cobelli, Francesco and Fiorino, Claudio 2023. Limited impact of discretization/interpolation parameters on the predictive power of CT radiomic features in a surgical cohort of pancreatic cancer patients. La Radiologia Medica 128 (7) , 799–807. 10.1007/s11547-023-01649-y

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Abstract

Purpose To explore the variation of the discriminative power of CT (Computed Tomography) radiomic features (RF) against image discretization/interpolation in predicting early distant relapses (EDR) after upfront surgery. Materials and methods Data of 144 patients with pre-surgical high contrast CT were processed consistently with IBSI (Image Biomarker Standardization Initiative) guidelines. Image interpolation/discretization parameters were intentionally changed, including cubic voxel size (0.21–27 mm3) and binning (32–128 grey levels) in a 15 parameter’s sets. After excluding RF with poor inter-observer delineation agreement (ICC < 0.80) and not negligible inter-scanner variability, the variation of 80 RF against discretization/interpolation was first quantified. Then, their ability in classifying patients with early distant relapses (EDR, < 10 months, previously assessed at the first quartile value of time-to-relapse) was investigated in terms of AUC (Area Under Curve) variation for those RF significantly associated to EDR. Results Despite RF variability against discretization/interpolation parameters was large and only 30/80 RF showed %COV < 20 (%COV = 100*STDEV/MEAN), AUC changes were relatively limited: for 30 RF significantly associated with EDR (AUC values around 0.60–0.70), the mean values of SD of AUC variability and AUC range were 0.02 and 0.05 respectively. AUC ranges were between 0.00 and 0.11, with values ≤ 0.05 in 16/30 RF. These variations were further reduced when excluding the extreme values of 32 and 128 for grey levels (Average AUC range 0.04, with values between 0.00 and 0.08). Conclusions The discriminative power of CT RF in the prediction of EDR after upfront surgery for pancreatic cancer is relatively invariant against image interpolation/discretization within a large range of voxel sizes and binning.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Engineering
Publisher: Springer
ISSN: 1826-6983
Date of First Compliant Deposit: 14 July 2023
Date of Acceptance: 15 May 2023
Last Modified: 08 Jun 2024 16:29
URI: https://orca.cardiff.ac.uk/id/eprint/160896

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