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Neurotrophin signalling in the human nervous system

Ateaque, Sarah, Merkouris, Spyros and Barde, Yves-Alain ORCID: 2023. Neurotrophin signalling in the human nervous system. Frontiers in Molecular Neuroscience 16 , 1225373. 10.3389/fnmol.2023.1225373

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This review focuses on neurotrophins and their tyrosine kinase receptors, with an emphasis on their relevance to the function and dysfunction in the human nervous system. It also deals with measurements of BDNF levels and highlights recent findings from our laboratory on TrkB and TrkC signalling in human neurons. These include ligand selectivity and Trk activation by neurotrophins and non-neurotrophin ligands. The ligand-induced down-regulation and re-activation of Trk receptors is also discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Additional Information: License information from Publisher: LICENSE 1: URL:
Publisher: Frontiers Media
ISSN: 1662-5099
Date of First Compliant Deposit: 19 July 2023
Date of Acceptance: 20 June 2023
Last Modified: 20 Jul 2023 02:36

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