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Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing

Wang, Zhihao, Knight, Rob, Stephens, Phil ORCID:, Ongkosuwito, E. M., Wagener, Frank A. D. T. G. and Von den Hoff, Johannes W. 2023. Stem cells and extracellular vesicles to improve preclinical orofacial soft tissue healing. Stem Cell Research and Therapy 14 (1) , 203. 10.1186/s13287-023-03423-3

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Orofacial soft tissue wounds caused by surgery for congenital defects, trauma, or disease frequently occur leading to complications affecting patients' quality of life. Scarring and fibrosis prevent proper skin, mucosa and muscle regeneration during wound repair. This may hamper maxillofacial growth and speech development. To promote the regeneration of injured orofacial soft tissue and attenuate scarring and fibrosis, intraoral and extraoral stem cells have been studied for their properties of facilitating maintenance and repair processes. In addition, the administration of stem cell-derived extracellular vesicles (EVs) may prevent fibrosis and promote the regeneration of orofacial soft tissues. Applying stem cells and EVs to treat orofacial defects forms a challenging but promising strategy to optimize treatment. This review provides an overview of the putative pitfalls, promises and the future of stem cells and EV therapy, focused on orofacial soft tissue regeneration.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: BioMed Central
ISSN: 1757-6512
Date of First Compliant Deposit: 16 August 2023
Date of Acceptance: 20 July 2023
Last Modified: 17 Aug 2023 03:02

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