Recent advances in catalysis using organoborane-mediated hydride abstraction

Pulis, Alexander P., Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531, Melen, Rebecca L. ORCID: https://orcid.org/0000-0003-3142-2831, Gillions, Joseph P., Elsherbeni, Salma A., Winfrey, Laura and Yun, Lei 2023. Recent advances in catalysis using organoborane-mediated hydride abstraction. Accounts and Rapid Communications in Chemical Synthesis 34 10.1055/a-2111-9629

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Abstract

C–H functionalization is widely regarded as an important area in the development of synthetic methodology, enabling the design of more time- and atom-efficient syntheses. The ability of electron-deficient organoboranes to mediate hydride abstraction from α-amino C–H bonds is therefore of great interest, as the reactive iminium and hydridoborate moieties generated are able to participate in a range of synthetically useful transformations. In this review, we cover the recent advances made in organoborane-mediated hydride abstraction, and focus on the catalytic applications of electron-deficient boranes in α- or β-functionalization, α,β-difunctionalization, and the dehydrogenation of amines.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	Thieme Gruppe
ISSN:	0936-5214
Funders:	EPSRC
Date of First Compliant Deposit:	7 September 2023
Date of Acceptance:	14 June 2023
Last Modified:	15 Sep 2023 18:37
URI:	https://orca.cardiff.ac.uk/id/eprint/162311

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