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Recent advances in catalysis using organoborane-mediated hydride abstraction

Pulis, Alexander P., Morrill, Louis C. ORCID:, Melen, Rebecca L. ORCID:, Gillions, Joseph P., Elsherbeni, Salma A., Winfrey, Laura and Yun, Lei 2023. Recent advances in catalysis using organoborane-mediated hydride abstraction. Accounts and Rapid Communications in Chemical Synthesis 34 10.1055/a-2111-9629

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C–H functionalization is widely regarded as an important area in the development of synthetic methodology, enabling the design of more time- and atom-efficient syntheses. The ability of electron-deficient organoboranes to mediate hydride abstraction from α-amino C–H bonds is therefore of great interest, as the reactive iminium and hydridoborate moieties generated are able to participate in a range of synthetically useful transformations. In this review, we cover the recent advances made in organoborane-mediated hydride abstraction, and focus on the catalytic applications of electron-deficient boranes in α- or β-functionalization, α,β-difunctionalization, and the dehydrogenation of amines.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: Thieme Gruppe
ISSN: 0936-5214
Funders: EPSRC
Date of First Compliant Deposit: 7 September 2023
Date of Acceptance: 14 June 2023
Last Modified: 15 Sep 2023 18:37

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