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Anisotropy in the human placenta in pregnancies complicated by fetal growth restriction

Slator, Paddy J. ORCID:, Ho, Alison, Bakalis, Spyros, Jackson, Laurence, Chappell, Lucy C., Alexander, Daniel C., Hajnal, Joseph V., Rutherford, Mary and Hutter, Jana 2021. Anisotropy in the human placenta in pregnancies complicated by fetal growth restriction. Özarslan, Evren, Schultz, Thomas, Zhang, Eugene and Fuster, Andrea, eds. Anisotropy Across Fields and Scales, Mathematics and Visualization, Springer, 263–276. (10.1007/978-3-030-56215-1_13)

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The placenta has a unique structure, which enables the transfer of oxygen and nutrients from the mother to the developing fetus. Abnormalities in placental structure are associated with major complications of pregnancy; for instance, changes in the complex branching structures of fetal villous trees are associated with fetal growth restriction. Diffusion MRI has the potential to measure such fine placental microstructural details. Here, we present in-vivo placental diffusion MRI scans from controls and pregnancies complicated by fetal growth restriction. We find that after 30 weeks’ gestation fractional anisotropy is significantly higher in placentas associated with growth restricted pregnancies. This shows the potential of diffusion MRI derived measures of anisotropy for assessing placental function during pregnancy.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Computer Science & Informatics
Publisher: Springer
ISBN: 978-3-030-56214-4
ISSN: 1612-3786
Date of First Compliant Deposit: 13 September 2023
Date of Acceptance: 2021
Last Modified: 02 Nov 2023 15:01

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