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Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin

Duggan, Katrina, Bentley, Kirsten ORCID:, Stanton, Richard J. ORCID: and Maillard, Jean-Yves ORCID: 2023. Evaluating the antimicrobial efficacy of long-lasting hand sanitisers on skin. Journal of Hospital Infection 10.1016/j.jhin.2023.08.020
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Background The microbicidal efficacy of hand sanitiser formulations is usually measured through standardized quantitative suspension tests and fingerpad tests; these cannot evaluate long-lasting formulations or are impractical due to biological risks, high cost, or time required for testing. With increased numbers of long-lasting microbicidal activity claims of commercially available hand sanitisers, alternative testing strategies are required. Aim To explore the use of a standardized ex-vivo pig skin model to reproducibly measure long-lasting efficacy of an alcohol-free hand sanitiser formulation. Methods The microbicidal efficacy of an alcohol-free hand sanitiser was tested against Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae, and the enveloped virus SARS-CoV-2 with quantitative suspension tests (EN13727 and EN14476) with a contact time of 5 min. The product was then tested over a 6-hour period using an ex-vivo pig skin model with a modified version of PAS 2424 to simulate the impact of skin abrasion. Findings Quantitative suspension tests yielded a > 5-log10 reduction for all organisms tested within a 5 min contact time. Pig skin tests showed reduced but consistent efficacy at all time points and indicated no significant impact of abrasion on efficacy. Conclusion The use of the ex-vivo pig skin model provides a potentially viable and convenient model system to test long-lasting hand sanitisers formulations, providing a path for sustainable hand sanitiser formulation claims of activity on skin.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Publisher: Elsevier
ISSN: 0195-6701
Funders: Accelerate
Date of First Compliant Deposit: 16 October 2023
Date of Acceptance: 24 August 2023
Last Modified: 15 Nov 2023 22:26

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