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Case Report: Response to ipilimumab and nivolumab in a patient with adrenocortical carcinoma

Charles, Rebecca, Madhu, Divine, Powles, Alexander, Boyde, Adam, Hughes, Owen, Kumar, Nagappan and Moorcraft, Sing Yu 2023. Case Report: Response to ipilimumab and nivolumab in a patient with adrenocortical carcinoma. Frontiers in Oncology 13 , 1242560. 10.3389/fonc.2023.1242560

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Background: Adrenocortical carcinoma (ACC) is a rare malignancy with limited treatment options. The evidence for the use of immunotherapy in ACC has been conflicting, with overall response rates ranging from 6 – 33%. Case presentation: We describe the case of a 32 year old patient who was initially thought to have an inoperable clear cell renal cell carcinoma and was treated with immunotherapy with ipilimumab and nivolumab. The patient had an excellent partial response to treatment. Further work-up prior to consideration of surgery demonstrated that the tumour was an ACC, rather than a renal cancer. She had a right adrenalectomy and right hepatectomy, achieving an R0 resection and remains disease-free one year after surgery. Conclusion: This case illustrates the challenge of diagnosing ACC, and that doublet immunotherapy with ipilimumab and nivolumab can have significant clinical efficacy in ACC.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Additional Information: License information from Publisher: LICENSE 1: URL:
Publisher: Frontiers Media
ISSN: 2234-943X
Date of First Compliant Deposit: 25 September 2023
Date of Acceptance: 11 August 2023
Last Modified: 26 Sep 2023 01:24

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