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Human iPSC-derived glia models for the study of neuroinflammation

Stoberl, Nina, Maguire, Emily, Salis, Elisa, Shaw, Bethany and Hall-Roberts, Hazel 2023. Human iPSC-derived glia models for the study of neuroinflammation. Journal of Neuroinflammation 20 , 231. 10.1186/s12974-023-02919-2

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Abstract

Neuroinflammation is a complex biological process that plays a significant role in various brain disorders. Microglia and astrocytes are the key cell types involved in inflammatory responses in the central nervous system. Neuroinflammation results in increased levels of secreted inflammatory factors, such as cytokines, chemokines, and reactive oxygen species. To model neuroinflammation in vitro, various human induced pluripotent stem cell (iPSC)-based models have been utilized, including monocultures, transfer of conditioned media between cell types, co-culturing multiple cell types, neural organoids, and xenotransplantation of cells into the mouse brain. To induce neuroinflammatory responses in vitro, several stimuli have been established that can induce responses in either microglia, astrocytes, or both. Here, we describe and critically evaluate the different types of iPSC models that can be used to study neuroinflammation and highlight how neuroinflammation has been induced and measured in these cultures.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher: BioMed Central
ISSN: 1742-2094
Funders: MRC
Date of First Compliant Deposit: 10 October 2023
Date of Acceptance: 2 October 2023
Last Modified: 17 Nov 2023 00:31
URI: https://orca.cardiff.ac.uk/id/eprint/163114

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