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Imprinted genes and the manipulation of parenting in mammals

John, Ros ORCID: https://orcid.org/0000-0002-3827-7617, Higgs, Matthew J. and Isles, Anthony R. ORCID: https://orcid.org/0000-0002-7587-5712 2023. Imprinted genes and the manipulation of parenting in mammals. Nature Reviews Genetics 24 10.1038/s41576-023-00644-3

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Abstract

Genomic imprinting refers to the parent-of-origin expression of genes, which originates from epigenetic events in the mammalian germ line. The evolution of imprinting may reflect a conflict over resource allocation early in life, with silencing of paternal genes in offspring soliciting increased maternal provision and silencing of maternal genes limiting demands on the mother. Parental caregiving has been identified as an area of potential conflict, with several imprinted genes serendipitously found to directly influence the quality of maternal care. Recent systems biology approaches, based on single-cell RNA sequencing data, support a more deliberate relationship, which is reinforced by the finding that imprinted genes expressed in the offspring influence the quality of maternal caregiving. These bidirectional, reiterative relationships between parents and their offspring are critical both for short-term survival and for lifelong wellbeing, with clear implications for human health.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Publisher: Nature Research
ISSN: 1471-0056
Date of First Compliant Deposit: 17 October 2023
Date of Acceptance: 25 July 2023
Last Modified: 28 Jan 2024 07:07
URI: https://orca.cardiff.ac.uk/id/eprint/163260

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