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Redefining ARDS: a paradigm shift

Villar, Jesús, Szakmany, Tamas ORCID:, Grasselli, Giacomo and Camporota, Luigi 2023. Redefining ARDS: a paradigm shift. Critical Care 27 (1) , 416. 10.1186/s13054-023-04699-w

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Although the defining elements of “acute respiratory distress syndrome” (ARDS) have been known for over a century, the syndrome was first described in 1967. Since then, despite several revisions of its conceptual definition, it remains a matter of debate whether ARDS is a discrete nosological entity. After almost 60 years, it is appropriate to examine how critical care has modeled this fascinating syndrome and affected patient’s outcome. Given that the diagnostic criteria of ARDS (e.g., increased pulmonary vascular permeability and diffuse alveolar damage) are difficult to ascertain in clinical practice, we believe that a step forward would be to standardize the assessment of pulmonary and extrapulmonary involvement in ARDS to ensure that each patient can receive the most appropriate and effective treatment. The selection of treatments based on arbitrary ranges of PaO2/FiO2 lacks sufficient sensitivity to individualize patient care.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: License information from Publisher: LICENSE 1: URL:, Type: open-access
Publisher: BioMed Central
ISSN: 1364-8535
Date of First Compliant Deposit: 1 November 2023
Date of Acceptance: 20 October 2023
Last Modified: 01 Nov 2023 10:00

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