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Impact of photodynamic therapy on different breast cancer subtypes in-vitro

Aske, Robin 2023. Impact of photodynamic therapy on different breast cancer subtypes in-vitro. PhD Thesis, Cardiff University.
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Photodynamic Therapy (PDT) is a novel therapeutic strategy. It is a type of phototherapy that involves activating an administered drug/chemical in the body with a specific wavelength of visible light to promote tumour cell death. Breast cancer (BC) is the leading cause of mortality in women globally. Indeed, while many luminal A patients have a better prognosis, some sub-types of the disease, such as triple negative, luminal B and HER2+ BC’s, are inherently more aggressive conferring poorer prognosis. Furthermore, many patients acquire resistance to current treatments resulting in disease recurrence and metastasis. PDT is a promising breast cancer (BC) treatment being explored in neoadjuvant, intraoperative, and recurrence settings, however responses are heterogeneous between patients. Deciphering this heterogeneity is required to understand how best to use PDT. The aim of this in-vitro project is to explore whether PDT sensitivity relates to the intrinsic phenotype of BC and to determine the underpinning response mechanism. An in-vitro PDT methodology was developed and optimized for use in various breast cancer cell lines, along with uptake, dark toxicity and phototoxicity studies. Open-access transcriptome analysis was conducted to identify potential PDT-response and PDT-resistant gene-sets/pathways. Consequently, the associated mechanistic changes that underpin PDT anti-tumour impact were further explored.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Pharmacy
Subjects: Q Science > Q Science (General)
Date of First Compliant Deposit: 6 November 2023
Last Modified: 06 Nov 2023 16:05

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