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Investigating the spatiotemporal summation of perimetric stimuli in dry age-related macular degeneration

Hunter, Aoife M.L., Anderson, Roger S., Redmond, Tony ORCID: https://orcid.org/0000-0002-6997-5231, Garway, David F. and Mulholland, Padraig J. 2023. Investigating the spatiotemporal summation of perimetric stimuli in dry age-related macular degeneration. Translational Vision Science & Technology 12 , 37. 10.1167/tvst.12.11.37

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Abstract

Purpose: To measure achromatic spatial, temporal, and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls under conditions of photopic gaze-contingent perimetry. Methods: Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco's area (RA) at 2.5° and 5° eccentricities along the 0°, 90°, 180°, and 270° meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7–190.4 ms) with a Goldmann III stimulus (GIII, 0.43°) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal summation (using the GIII stimulus) and spatiotemporal summation (using the RA stimuli) was estimated using iterative two-phase regression analysis. Results: Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09–0.41] deg2; 5°: 0.32 [0.15–0.65 deg2]) compared to healthy controls (2.5°: 0.08 [0.05–0.13] deg2; 5°: 0.15 [0.08–0.22] deg2) at all test locations (all P < 0.05). No significant difference in median critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9–30.4] ms) and RA-scaled stimuli (22.9 [13.9–40.3] ms) compared to healthy controls (GIII: 17.0 [11.3–24.0] ms; RA-scaled: 22.4 [14.3–33.1] ms) at all test locations (all P > 0.05). Conclusions: Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance: The sensitivity of perimetry to AMD may be improved by utilizing stimuli that probe alterations in spatial summation in the disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Publisher: Association for Research in Vision and Ophthalmology
ISSN: 2164-2591
Funders: Macular Society
Date of First Compliant Deposit: 8 November 2023
Date of Acceptance: 26 September 2023
Last Modified: 12 Dec 2023 09:56
URI: https://orca.cardiff.ac.uk/id/eprint/163741

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