Comparison of subjective grading and objective assessment in meibography.

Pult, Heiko ORCID: https://orcid.org/0000-0003-4371-8007 and Riede-Pult, Britta 2013. Comparison of subjective grading and objective assessment in meibography. Contact Lens & Anterior Eye 36 (1) , pp. 22-27. 10.1016/j.clae.2012.10.074

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Abstract

Aim To analyse repeatability of subjective grading and objective assessment in non-contact infra-red meibography. Methods Meibography photographs of 24 subjects (female 14; mean age = 46; range = 19–69 years, upper-lid images = 12, lower-lid images = 12) were classified in two sessions by three experienced observers (OI, OII, OIII). Relative area or portion affected by meibomian glands (MG) loss was classified applying three different grading scales in randomized order: a four-grade scale (4S) (degree 0 = no partial glands; 1 = <25% partial glands; 3 = 25–75% partial glands; 3 = >75% partial glands), a pictorial five-grade scale (5S) (degree 0 = no meibomian gland loss (MGL); 1 = <25% MGL; 3 = 26–50% MGL; 3 = 51–75%; 4 = >75% MGL) and objectively by a 100-grade scale (DA) applying ImageJ software. Results Observed MG loss ranged from 0% to 69%. Intra-observer agreement of the 5S (OI: κ = 0.80, p < 0.001; OII: κ = 0.40, p = 0.009; OIII κ = 0.81, p < 0.001) was better than of the 4S (OI: κ = 0.79, p < 0.001; OII: κ = 0.15, p = 0.342; OIII κ = 0.50, p = 0.0071). Intra-observer agreement of OI and OIII (±0.88 (95% confidence interval), ±1.305) was better than of OII (±2.21) in 4S and 5S (±0.99, ±2.00 and ±0.91; OI, OII and OIII, respectively) while it was relatively similar in DA (±18, ±17 and ±17). Inter-observer agreement was better in DA (OI–OII: ±13, OI–OII: ±19, OII–OIII: ±26) than in 4S (OI–OII: ±1.76; OI–OIII: ±1.29 and OII–OIII: ±1.31) or 5S (OI–OII: ±1.49; OI–OIII: ±0.91 and OII–OIII: ±1.20). Conclusion Intra-observer and inter-observer agreement was better in computerized grading followed by the subjective five-grade scale and four-grade scale.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Optometry and Vision Sciences
Publisher:	Elsevier
ISSN:	1367-0484
Date of Acceptance:	2 October 2012
Last Modified:	29 Nov 2023 16:30
URI:	https://orca.cardiff.ac.uk/id/eprint/164168

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