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Unravelling the respiratory health path across the lifespan for survivors of preterm birth

Simpson, Shannon J., Du Berry, Cassidy, Evans, Denby J., Gibbons, James T. D., Vollsæter, Maria, Halvorsen, Thomas, Gruber, Karl, Lombardi, Enrico, Stanojevic, Sanja, Hurst, John R., Um-Bergström, Petra, Hallberg, Jenny, Doyle, Lex W. and Kotecha, Sailesh ORCID: 2024. Unravelling the respiratory health path across the lifespan for survivors of preterm birth. The Lancet Respiratory Medicine 12 (2) , pp. 167-180. 10.1016/S2213-2600(23)00272-2

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Many survivors of preterm birth will have abnormal lung development, reduced peak lung function and, potentially, an increased rate of physiological lung function decline, each of which places them at increased risk of chronic obstructive pulmonary disease across the lifespan. Current rates of preterm birth indicate that by the year 2040, around 50 years since the introduction of surfactant therapy, more than 700 million individuals will have been born prematurely—a number that will continue to increase by about 15 million annually. In this Personal View, we describe current understanding of the impact of preterm birth on lung function through the life course, with the aim of putting this emerging health crisis on the radar for the respiratory community. We detail the potential underlying mechanisms of prematurity-associated lung disease and review current approaches to prevention and management. Furthermore, we propose a novel way of considering lung disease after preterm birth, using a multidimensional model to determine individual phenotypes of lung disease—a first step towards optimising management approaches for prematurity-associated lung disease.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
ISSN: 2213-2600
Funders: MRC
Date of First Compliant Deposit: 28 November 2023
Date of Acceptance: 20 July 2023
Last Modified: 13 Feb 2024 17:06

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