Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis

Jörgensen, Sara K. M., Karnosová, Alena, Mazzaferro, Simone, Rowley, Oliver, Chen, Hsiao-Jou Cortina, Robbins, Sarah J., Christofides, Sarah, Merkle, Florian T., Maletínská, Lenka and Petrik, David ORCID: 2024. An analogue of the Prolactin Releasing Peptide reduces obesity and promotes adult neurogenesis. EMBO Reports 25 (1) , pp. 351-377. 10.1038/s44319-023-00016-2

[thumbnail of jörgensen-et-al-2023-an-analogue-of-the-prolactin-releasing-peptide-reduces-obesity-and-promotes-adult-neurogenesis.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (11MB) | Preview


Hypothalamic Adult Neurogenesis (hAN) has been implicated in regulating energy homeostasis. Adult-generated neurons and adult Neural Stem Cells (aNSCs) in the hypothalamus control food intake and body weight. Conversely, diet-induced obesity (DIO) by high fat diets (HFD) exerts adverse influence on hAN. However, the effects of anti-obesity compounds on hAN are not known. To address this, we administered a lipidized analogue of an anti-obesity neuropeptide, Prolactin Releasing Peptide (PrRP), so-called LiPR, to mice. In the HFD context, LiPR rescued the survival of adult-born hypothalamic neurons and increased the number of aNSCs by reducing their activation. LiPR also rescued the reduction of immature hippocampal neurons and modulated calcium dynamics in iPSC-derived human neurons. In addition, some of these neurogenic effects were exerted by another anti-obesity compound, Liraglutide. These results show for the first time that anti-obesity neuropeptides influence adult neurogenesis and suggest that the neurogenic process can serve as a target of anti-obesity pharmacotherapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Wiley
ISSN: 1469-3178
Date of First Compliant Deposit: 4 January 2024
Date of Acceptance: 17 November 2023
Last Modified: 13 Feb 2024 14:39

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics