Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T

Read, Marie-Lucie, Berry, Samuel C., Graham, Kim S., Voets, Natalie L., Zhang, Jiaxiang ORCID: https://orcid.org/0000-0002-4758-0394, Aggleton, John P. ORCID: https://orcid.org/0000-0002-5573-1308, Lawrence, Andrew D. ORCID: https://orcid.org/0000-0001-6705-2110 and Hodgetts, Carl J. ORCID: https://orcid.org/0000-0002-0339-2447 2024. Scene-selectivity in CA1/subicular complex: Multivoxel pattern analysis at 7T. Neuropsychologia 194 , 108783. 10.1016/j.neuropsychologia.2023.108783

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Abstract

Prior univariate functional magnetic resonance imaging (fMRI) studies in humans suggest that the anteromedial subicular complex of the hippocampus is a hub for scene-based cognition. However, it is possible that univariate approaches were not sufficiently sensitive to detect scene-related activity in other subfields that have been implicated in spatial processing (e.g., CA1). Further, as connectivity-based functional gradients in the hippocampus do not respect classical subfield boundary definitions, category selectivity may be distributed across anatomical subfields. Region-of-interest approaches, therefore, may limit our ability to observe category selectivity across discrete subfield boundaries. To address these issues, we applied searchlight multivariate pattern analysis to 7T fMRI data of healthy adults who undertook a simultaneous visual odd-one-out discrimination task for scene and non-scene (including face) visual stimuli, hypothesising that scene classification would be possible in multiple hippocampal regions within, but not constrained to, anteromedial subicular complex and CA1. Indeed, we found that the scene-selective searchlight map overlapped not only with anteromedial subicular complex (distal subiculum, pre/para subiculum), but also inferior CA1, alongside posteromedial (including retrosplenial) and parahippocampal cortices. Probabilistic overlap maps revealed gradients of scene category selectivity, with the strongest overlap located in the medial hippocampus, converging with searchlight findings. This was contrasted with gradients of face category selectivity, which had stronger overlap in more lateral hippocampus, supporting ideas of parallel processing streams for these two categories. Our work helps to map the scene, in contrast to, face processing networks within, and connected to, the human hippocampus.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0028-3932
Date of First Compliant Deposit:	5 January 2024
Date of Acceptance:	27 December 2023
Last Modified:	21 Mar 2024 11:06
URI:	https://orca.cardiff.ac.uk/id/eprint/165286

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