The role of Ureaplasma spp. in the development of Nongonococcal Urethritis and infertility among Men

Beeton, Michael L., Payne, Matthew S. and Jones, Lucy ORCID: https://orcid.org/0000-0002-3872-4376 2019. The role of Ureaplasma spp. in the development of Nongonococcal Urethritis and infertility among Men. Clinical Microbiology Reviews 32 (4) 10.1128/cmr.00137-18

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Abstract

Ureaplasma spp. are a genus of bacteria for which two human-associated species exist: Ureaplasma urealyticum and Ureaplasma parvum. Their definition as a pathogen in the context of nongonococcal urethritis (NGU) and infertility among males remains highly controversial, largely due to historically high rates of isolation of these bacteria from the urethra of seemingly healthy men. This review summarizes the emerging evidence suggesting a true pathogenic role of these bacteria under specific conditions, which we term risk factors. We examine the historical, clinical, and experimental studies which support a causal role for Ureaplasma spp. in the development of NGU as well as some of the proposed mechanisms behind the association of Ureaplasma spp. and the development of infertility. Finally, we discuss the potential for developing a case-by-case risk-based approach toward the management of men who present with seemingly idiopathic NGU but who are positive for Ureaplasma spp

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Society for Microbiology
ISSN:	0893-8512
Last Modified:	19 Jan 2024 15:45
URI:	https://orca.cardiff.ac.uk/id/eprint/165449

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