Pradhan, Tapas R. ![]() |
Official URL: https://doi.org/10.1002/adsc.201900314
Abstract
A metal-free oxyacetoxylation method of primary, secondary and tertiary propargylic carboxylates with retention of chirality was presented. The reaction proceeds through the intramolecular nucleophilic attack of the neighboring carbonyl group on an alkynyliodonium intermediate. The process is general with broad substrate scope and is amenable for application to a variety of propargyl carboxylates including those obtained from natural products. Insight into the mechanistic pathway by isotopic labelling (using H2O18 and D2O) and controlled experiments confirmed.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | Wiley |
ISSN: | 1615-4150 |
Last Modified: | 16 May 2024 01:39 |
URI: | https://orca.cardiff.ac.uk/id/eprint/165580 |
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