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Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies

Milczarek, Michal M., Perry, James C., Amin, Eman, Haniffa, Salma, Hathaway, Thomas and Vann, Seralynne D. ORCID: https://orcid.org/0000-0002-6709-8773 2024. Impairments in the early consolidation of spatial memories via group II mGluR agonism in the mammillary bodies. Scientific Reports 14 , 5977. 10.1038/s41598-024-56015-3

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Abstract

mGluR2 receptors are widely expressed in limbic brain regions associated with memory, including the hippocampal formation, retrosplenial and frontal cortices, as well as subcortical regions including the mammillary bodies. mGluR2/3 agonists have been proposed as potential therapeutics for neurological and psychiatric disorders, however, there is still little known about the role of these receptors in cognitive processes, including memory consolidation. To address this, we assessed the efect of the mGluR2/3 agonist, eglumetad, on spatial memory consolidation in both mice and rats. Using the novel place preference paradigm, we found that post-sample injections of eglumetad impaired subsequent spatial discrimination when tested 6 h later. Using the immediate early gene c-fos as a marker of neural activity, we showed that eglumetad injections reduced activity in a network of limbic brain regions including the hippocampus and mammillary bodies. To determine whether the systemic efects could be replicated with more targeted manipulations, we performed post-sample infusions of the mGluR2/3 agonist 2R,4R-APDC into the mammillary bodies. This impaired novelty discrimination on a place preference task and an object-in-place task, again highlighting the role of mGluR2/3 transmission in memory consolidation and demonstrating the crucial involvement of the mammillary bodies in post-encoding processing of spatial information.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Psychology
Publisher: Nature Research
ISSN: 2045-2322
Funders: Wellcome Trust, BBSRC
Date of First Compliant Deposit: 14 March 2024
Date of Acceptance: 29 February 2024
Last Modified: 17 Apr 2024 13:38
URI: https://orca.cardiff.ac.uk/id/eprint/166854

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