Diagnostic efficacy of advanced ultrasonography imaging techniques in infants with biliary atresia (BA): a systematic review and meta-analysis

Takadiyi Gunda, Simon, Chambara, Nonhlanhla ORCID: https://orcid.org/0000-0002-3183-883X, Chen, Xiangyan Fiona, Pang, Marco Yiu Chung and Ying, Michael Tin-cheung 2022. Diagnostic efficacy of advanced ultrasonography imaging techniques in infants with biliary atresia (BA): a systematic review and meta-analysis. Children 9 (11) , 1676. 10.3390/children9111676

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Abstract

The early diagnosis of biliary atresia (BA) in cholestatic infants is critical to the success of the treatment. Intraoperative cholangiography (IOC), an invasive imaging technique, is the current strategy for the diagnosis of BA. Ultrasonography has advanced over recent years and emerging techniques such as shear wave elastography (SWE) have the potential to improve BA diagnosis. This review sought to evaluate the diagnostic efficacy of advanced ultrasonography techniques in the diagnosis of BA. Six databases (CINAHL, Medline, PubMed, Google Scholar, Web of Science (core collection), and Embase) were searched for studies assessing the diagnostic performance of advanced ultrasonography techniques in differentiating BA from non-BA causes of infantile cholestasis. The meta-analysis was performed using Meta-DiSc 1.4 and Comprehensive Meta-analysis v3 software. Quality Assessment of Diagnostic Accuracy Studies tool version 2 (QUADAS-2) assessed the risk of bias. Fifteen studies consisting of 2185 patients (BA = 1105; non-BA = 1080) met the inclusion criteria. SWE was the only advanced ultrasonography technique reported and had a good pooled diagnostic performance (sensitivity = 83%; specificity = 77%; AUC = 0.896). Liver stiffness indicators were significantly higher in BA compared to non-BA patients (p < 0.000). SWE could be a useful tool in differentiating BA from non-BA causes of infantile cholestasis. Future studies to assess the utility of other advanced ultrasonography techniques are recommended.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Healthcare Sciences
Publisher:	MDPI
ISSN:	2227-9067
Date of Acceptance:	27 October 2022
Last Modified:	22 Mar 2024 11:45
URI:	https://orca.cardiff.ac.uk/id/eprint/167154

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