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Design and synthesis of luminescent probes aimed at biologically important targets

Alenazy, Deemah 2023. Design and synthesis of luminescent probes aimed at biologically important targets. PhD Thesis, Cardiff University.
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This thesis further developed the synthesis of numerous novel fluorescent functionalised species and provided in-depth analyses of their photophysical characteristics and potential for use in imaging, sensing, and therapeutic applications. In Chapter 2, the approach aimed to develop the synthetic chemistry of a wide range of novel fluorescent functionalised naphthylamide species containing piperazine binding site. Then investigations were completed into the chemistry of these species with the cholesterol conjugates species. A series of cholesterol functionalised naphthylamide was successfully completed. Once synthesised it was intended for cholesterol species to be spectroscopically and analytically characterised. This provided data indicating their synthesis with spectroscopic studies being particularly important for characterising the compounds and their electronic properties. Chapter 3 has described the synthesis, structural, and spectroscopic properties of a variety of mono- and disubstituted anthraquinone species containing various substituted amines. A number of biological studies, including cytotoxicity assessment, were conducted on selected AQ species. The presence of various amine groups on the AQ core has a significant impact on biological behavior. Chapter 4 described the synthesis of the new substituted aza-anthraquinone series, which yielded eight new species. The structural variants attempt to strike a balance between hydrophilic and lipophilic properties. The photophysical data displaying emission properties in the red region with favourable characteristics towards potential cell imaging applications clearly shows that the species discussed herein are clearly interested. ii Chapter 5 describes the successful synthesis of four photoactive compounds containing both anthraquinone and naphthalimide fluorophores. The nature of the linking amine unit differs between the species. The dual NAP-AQ core's design allows the physical properties to be tuned to a high degree of functionality. The species covered in this chapter are undeniably intriguing, and photophysical data show intense emission characteristics that might be useful for cell imaging applications.

Item Type: Thesis (PhD)
Date Type: Completion
Status: Unpublished
Schools: Chemistry
Date of First Compliant Deposit: 9 April 2024
Last Modified: 11 Apr 2024 08:58

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