Khot, Sharmila ORCID: https://orcid.org/0000-0003-4677-5680, Tackley, George ORCID: https://orcid.org/0000-0002-7464-7662 and Choy, Ernest ORCID: https://orcid.org/0000-0003-4459-8609 2024. How to distinguish non-inflammatory from inflammatory pain in RA? Current Rheumatology Reports 10.1007/s11926-024-01159-4 |
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Abstract
Purpose of the Review Managing non-inflammatory pain in rheumatoid arthritis (RA) can be a huge burden for the rheumatologist. Pain that persists despite optimal RA treatment is extremely challenging for patient and physician alike. Here, we outline the latest research relevant to distinguishing non-inflammatory from inflammatory RA pain and review the current understanding of its neurobiology and management. Recent Findings Nociplastic pain is a recently introduced term by the international pain community. Its definition encompasses the non-inflammatory pain of RA and describes pain that is not driven by inflamed joints or compromised nerves, but that is instead driven by a functional reorganisation of the central nervous system (CNS). Summary Insights from all areas of nociplastic pain research, including fibromyalgia, support a personalised pain management approach for non-inflammatory pain of RA, with evidence-based guidelines favouring use of non-pharmacological interventions. Future developments include novel CNS targeting pharmacotherapeutic approaches to treat nociplastic pain.
Item Type: | Article |
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Date Type: | Published Online |
Status: | In Press |
Schools: | Psychology Cardiff University Brain Research Imaging Centre (CUBRIC) |
Publisher: | Current Medicine Group |
ISSN: | 1523-3774 |
Date of First Compliant Deposit: | 16 August 2024 |
Date of Acceptance: | 17 July 2024 |
Last Modified: | 26 Sep 2024 01:06 |
URI: | https://orca.cardiff.ac.uk/id/eprint/171290 |
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