Implication of capillary morphogenesis gene 2 (CMG2) in the disease progression and peritoneal metastasis of pancreatic cancer

Fang, Ziqian, Bunston, Carly, Xu, Yali, Ruge, Fiona, Sui, Laijian, Liu, Ming, Al-Sarireh, Bilal, Griffiths, Paul, Murphy, Kate, Pugh, Matthew R., Hao, Chunyi, Jiang, Wen G. ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2024. Implication of capillary morphogenesis gene 2 (CMG2) in the disease progression and peritoneal metastasis of pancreatic cancer. Cancers 16 (16) , 2893. 10.3390/cancers16162893

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Abstract

Simple Summary: Pancreatic cancer remains as one of the most life-threatening cancers with a 5-year overall survival rate less than 6%. As a transmembrane protein, capillary formation gene 2 (CMG2) mediates cell–matrix adhesion and migration. Recent studies have revealed emerging roles of CMG2 in various cancers. This study aimed to evaluate expression of CMG2 in pancreatic cancer and its implication in the disease progression and distant metastasis. Interestingly, the significant upregulation of CMG2 was seen in pancreatic cancer, which was associated with poor survival and distant metastases highlighting the potential of targeting this molecule for the prevention of dissemination of pancreatic cancer cells. Abstract: Capillary morphogenesis gene 2 (CMG2) mediates cell–matrix interactions to facilitate cell adhesion and migration. CMG2 has been implicated in the disease progression of breast cancer, prostate cancer and gastric cancer. The present study aims to determine the role of CMG2 in the disease progression and peritoneal metastasis of pancreatic cancer. Pancreatic tumour samples were collected from Peking University Cancer Hospital. CMG2 expression was determined using quantitative PCR. After the creation of knockdown and overexpression of CMG2 in pancreatic cancer cells, the effect of CMG2 on several cell functions and adhesion to the peritoneum was examined. Potential pathways regulated by CMG2 were found via proteomics analysis and drug tests. CMG2 was upregulated in pancreatic cancer tissues and associated with a poor prognosis. CMG2 was increased in metastatic lesions and those primary tumours with distant metastases. CMG2 promotes cell–cell, cell–matrix and cell–hyaluronic acid adhesion, which may be mediated by epidermal growth factor receptor (EGFR) and focal adhesion kinase (FAK) pathway activation.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	?? VCO ?? Medicine Mathematics
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
Date of First Compliant Deposit:	9 September 2024
Date of Acceptance:	17 August 2024
Last Modified:	09 Sep 2024 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/171931

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