Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort

Wade, Kaitlin H., Lam, Brian Y. H., Melvin, Audrey, Pan, Warren, Corbin, Laura J., Hughes, David A., Rainbow, Kara, Chen, Jian-Hua, Duckett, Katie, Liu, Xiaoming, Mokrosiński, Jacek, Mörseburg, Alexander, Neaves, Sam ORCID: https://orcid.org/0000-0002-4064-3794, Williamson, Alice, Zhang, Chen, Farooqi, I. Sadaf, Yeo, Giles S. H., Timpson, Nicholas J. and O’Rahilly, Stephen 2021. Loss-of-function mutations in the melanocortin 4 receptor in a UK birth cohort. Nature Medicine 27 (6) , pp. 1088-1096. 10.1038/s41591-021-01349-y

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Abstract

Mutations in the melanocortin 4 receptor gene (MC4R) are associated with obesity but little is known about the prevalence and impact of such mutations throughout human growth and development. We examined the MC4R coding sequence in 5,724 participants from the Avon Longitudinal Study of Parents and Children, functionally characterized all nonsynonymous MC4R variants and examined their association with anthropometric phenotypes from childhood to early adulthood. The frequency of heterozygous loss-of-function (LoF) mutations in MC4R was ~1 in 337 (0.30%), considerably higher than previous estimates. At age 18 years, mean differences in body weight, body mass index and fat mass between carriers and noncarriers of LoF mutations were 17.76 kg (95% CI 9.41, 26.10), 4.84 kg m−2 (95% CI 2.19, 7.49) and 14.78 kg (95% CI 8.56, 20.99), respectively. MC4R LoF mutations may be more common than previously reported and carriers of such variants may enter adult life with a substantial burden of excess adiposity.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	1078-8956
Date of Acceptance:	12 April 2021
Last Modified:	14 Nov 2024 11:01
URI:	https://orca.cardiff.ac.uk/id/eprint/172263

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