Subcutaneous administration of natalizumab can lead to lower drug concentrations compared to intravenous administration

Gelissen, Liza M.Y., Loveless, Sam ORCID: https://orcid.org/0000-0002-5124-4115, Toorop, Alyssa A., Howlett, Jayne, Loeff, Floris C., Rispens, Theo, Killestein, Joep, Tallantyre, Emma C. ORCID: https://orcid.org/0000-0002-3760-6634 and van Kempen, Zoé L.E. 2024. Subcutaneous administration of natalizumab can lead to lower drug concentrations compared to intravenous administration. Multiple Sclerosis and Related Disorders 90 , 105796. 10.1016/j.msard.2024.105796 Item availability restricted.

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Abstract

Background Several studies reported lower drug concentrations with subcutaneous natalizumab compared to intravenous natalizumab. With the emergence of extended interval dosing, gaining more insight into lower concentrations after subcutaneous administration is essential. Methods We compared serum trough concentrations between subcutaneous and intravenous administration within a matched cohort (n = 50). Results Subcutaneous administration (n = 25) was associated with lower concentrations compared to intravenous administration (n = 25) (log-B=-0.28, p = 0.01). In an exploratory group of 11 patients receiving extended interval dosing of subcutaneous natalizumab, the median trough concentration was even lower. Conclusion Subcutaneous natalizumab can lead to lower drug concentrations, potentially limiting extended interval dosing.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	2211-0348
Date of First Compliant Deposit:	8 October 2024
Date of Acceptance:	29 July 2024
Last Modified:	07 Nov 2024 19:15
URI:	https://orca.cardiff.ac.uk/id/eprint/172662

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