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Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway.

Frasca, Angelisa, Miramondi, Federica, Butti, Erica, Indrigo, Marzia, Balbontin Arenas, Maria, Postogna, Francesca M., Piffer, Arianna, Bedogni, Francesco, Pizzamiglio, Lara, Cambria, Clara, Borello, Ugo, Antonucci, Flavia, Martino, Gianvito and Landsberger, Nicoletta 2024. Neural precursor cells rescue symptoms of Rett syndrome by activation of the Interferon γ pathway. EMBO Molecular Medicine 16 (12) , pp. 3218-3246. 10.1038/s44321-024-00144-9

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Abstract

The beneficial effects of Neural Precursor Cell (NPC) transplantation in several neurological disorders are well established and they are generally mediated by the secretion of immunomodulatory and neurotrophic molecules. We therefore investigated whether Rett syndrome (RTT), that represents the first cause of severe intellectual disability in girls, might benefit from NPC-based therapy. Using in vitro co-cultures, we demonstrate that, by sensing the pathological context, NPC-secreted factors induce the recovery of morphological and synaptic defects typical of Mecp2 deficient neurons. In vivo, we prove that intracerebral transplantation of NPCs in RTT mice significantly ameliorates neurological functions. To uncover the molecular mechanisms underpinning the mediated benefic effects, we analyzed the transcriptional profile of the cerebellum of transplanted animals, disclosing the possible involvement of the Interferon γ (IFNγ) pathway. Accordingly, we report the capacity of IFNγ to rescue synaptic defects, as well as motor and cognitive alterations in Mecp2 deficient models, thereby suggesting this molecular pathway as a potential therapeutic target for RTT. [Abstract copyright: © 2024. The Author(s).]

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Springer
ISSN: 1757-4676
Date of First Compliant Deposit: 16 October 2024
Date of Acceptance: 4 September 2024
Last Modified: 15 Jan 2025 14:59
URI: https://orca.cardiff.ac.uk/id/eprint/172966

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